Allergy project
A novel
long-acting
lgE Trap-Fc fusion protein
GI-301
Features
Features
- A novel long-acting lgE Trap-Fc fusion protein for allergic diseases
-
Broad therapeutic efficacy for IgE-mediated hypersensitivity reaction
Sufficient IgE control capacity for patients with high IgE levels
Low risk of anaphylactic shock and immunogenicity
High safety in GLP toxicity study
DESCRIPTION
Mechanism
- Core Mechanism GI-301
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Hypersensitivity reaction
When the immune system is exposed to foreign antigens, IgE and autoantibody (anti-FcεR1α) are expressed.
These antibodies can bind to FcεR1α of mast cells, activating the cells.
Activated mast cells release histamine, increasing blood histamine levels causing hypersensitivity reaction. -
Dual action of GI-301
GI-301 has two functional groups that can each bind to IgE and autoantibody (anti-FcεR1α) with high affinity, inhibiting the activation of mast cells.
Mast cell deactivation decreases the histamine concentration in the blood, alleviating hypersensitivity reaction.